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Meet Dr. Jessica Duis:

Bridging Breakthrough Science and Human Connection

Delivering on the promise of highly personalized, direct-access care requires more than just good intentions—it requires a physician who has been at the absolute forefront of rare disease science.

Dr. Jessica Duis, MD, MS, is a board-certified neurogeneticist and pediatrician. She built this practice to solve a critical gap in rare disease care: the disconnect between world-class genomic research and the daily, lived experience of patients and their families.

As a true "translational architect," Dr. Duis doesn't just read the latest medical literature; she has spent her career helping write it.

A World-Class Clinical Pedigree

Dr. Duis’s background is rooted in the highest tiers of medical research and clinical care:

  • Top-Tier Training: She completed her medical training at the Johns Hopkins University School of Medicine.

  • Pioneering Patient Care: She has founded and directed multidisciplinary Centers of Excellence for rare diseases at leading institutions, including Vanderbilt University Medical Center and the University of Colorado/Children's Hospital Colorado. These centers served individuals with Angelman syndrome, Prader-Willi syndrome, duplication 15q syndrome, developmental epileptic encephalopathies (DEEs), musculoskeletal disorders, neuromuscular disease, connective tissue disease, and vascular anomalies.

  • Leading the Future of Medicine: Beyond the clinic, Dr. Duis is a Clinical Leader and  Clinical Development Executive who has designed and executed innovative clinical trials for breakthrough therapies. She has extensive experience collaborating with the FDA and EMA to accelerate pathways for orphan drugs, meaning she deeply understands the cutting-edge therapies on the horizon for her patients.

Dr. Duis’s true passion has always been advocating for and serving individuals with rare diseases. She recognized that the traditional healthcare system—with its rushed 15-minute appointments and bureaucratic gatekeepers—could not adequately support the complex, whole-person care her patients deserved.

"My goal is to bring the precision of genomic science out of the laboratory and into your life. By removing the barriers of traditional healthcare, I can be the direct, dedicated partner you need to thrive—not just survive—with a rare condition."

Certifications

Being Board Certified in both the American Board of Medical Genetics and Genomics, American Board of Pediatrics, Dr. Duis provides both comprehensive pediatric and adult care as well as advanced diagnostic and management expertise in rare and inherited disorders.

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Areas of Focus

  • We provide a longitudinal medical home for both children and adults. Our approach moves beyond managing isolated symptoms to addressing the interconnected, multisystem nature of rare disease. By managing the "whole person," we ensure continuity of care as patients transition through every stage of life—from early childhood development to adult community support and care.

  • Utilizing deep genomic expertise to provide diagnostic clarity, Dr. Duis leverages her background in translational science and clinical development to interpret complex genetic data, offering answers to those on a "diagnostic odyssey" and providing a clear roadmap for those with known conditions.

  • We have eliminated the traditional barriers of the healthcare system. By removing gatekeepers and call centers, we ensure patients have a direct line to their physician. This model allows for timely intervention during flares, immediate answers to complex questions, and a level of security that "rare" families seldom experience.

  • We empower families to become experts in their own care. This includes dedicated school advocacy—navigating IEP and 504 processes to ensure educational environments support the child’s unique needs—as well as providing the latest evidence-based education on rare disease progression and emerging therapies.

  • For patients with lifelong conditions, the move from pediatric to adult medicine is often a point of crisis. We specialize in transition planning, ensuring that the specialized care, therapy, and support systems built in childhood are successfully translated and maintained in the adult medical world. We remain a consistent care partner throughout life even when other providers are changing.

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Clinical Specialties

Dr. Duis provides expert diagnosis and longitudinal management for a broad spectrum of complex conditions. Her approach utilizes the deep knowledge of complex and rare disorders and thoughtful innovative thinking for the whole person  to create individualized plans for living.

Multisystemic disease:

  • Chromosomal Disorders

  • Complex care coordination

  • Undiagnosed disorders

  • Rare genetic diseases

Neurogenetic & Neurodevelopmental Conditions

  • Complex Neurogenetic Disorders

  • Developmental Epileptic Encephalopathies (DEE)

  • Neuromuscular Disorders

  • Neurodegenerative Conditions:

  • Developmental & Behavioral Care (including autism and ADHD)

Rare Genetic Causes of Obesity & Neuroendocrine Disease

  • MC4R Pathway Disorders

  • Syndromic Obesity

  • Neuroendocrine Dysfunction.

Inborn Errors of Metabolism (IEM)

  • Metabolic Management

  • Complex Metabolic Care

  • Lysosomal & Peroxisomal Disorders

Connective Tissue Disorders & Fibrinopathies

  • Fibrinopathies & TGF-beta Vasculopathies

  • Ehlers-Danlos Syndromes (EDS)

  • Hypermobility & Comorbidities